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+---- Thread: FORESEEN - Test Methods (/showthread.php?tid=187)
FORESEEN - Test Methods - Clemens Wittwehr - 21 Feb 2022
The ultimate goal of the AOP framework is to mechanistically explain and depict toxicity in a way that allows New Approach Methods (NAMs) to detect and measure AOP Key Events so that that their results be accepted in regulatory contexts – which in turn will lead to a better association of stressor chemicals to the AOPs they are involved in. AOP Key Events must be measurable and detectable in order to play a role in an AOP. That is also the reason why there is a free text section "How it is measured or detected" on the Key Event page (e.g. https://aopwiki.org/events/265#measured). However, in this current free text form, the AOP-Wiki does not focus enough on the role of relevant test methods, which makes the desired association between chemicals and AOPs scientifically difficult, and impossible in a regulatory context.
The international project Methods2AOP is currently addressing these issues, and the team envisions:
- A change to the AOP-Wiki data model and functionality reflecting the importance of test methods,
- ways to open the AOP framework up to the test method developers community,
- and plans to incorporate the suggestions into the OECD plans for the AOP program.
The attached PowerPoint Slides (PDF) give a short introduction to the Methods2AOP project.