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+---- Thread: Inclusion of evidence for domain of applicability (/showthread.php?tid=215)
Inclusion of evidence for domain of applicability - clalone - 29 Jun 2023
See pptx for visual description and Jensen et al., 2023 for details:
Jensen, M. A., Blatz, D. J., & LaLone, C. A. (2023). Defining the biologically plausible taxonomic domain of applicability of an adverse outcome pathway: A case study linking nicotinic acetylcholine receptor activation to colony death. Environmental Toxicology and Chemistry, 42(1), 71-87.
Domain of applicability for Key Events (KE) in AOP-Wiki Tables:
List species, sex, life stage from empirical studies (in vitro and in vivo)
Define list of species for biologically plausible taxonomic domain of applicability (in silico) - can be pulled from 3rd party tools (e.g., SeqAPASS)
Domain of applicability for Key Event Relationships (KER) in AOP-Wiki Tables with evidence in free text:
Define Plausible Taxonomic Domain of Applicability where KEup list of species matches KEdown list of species (narrowest DOA; Jensen et al., 2023)
-This info is derived from empirical studies that support the KEs and through lines of evidence toward structural and functional conservation for plausible taxonomic DOA
-Life stage and Sex can be combined with taxonomic tDOA
-Machine readable tables with links out to details for evidence calls in free text
-Ensure DOA categories are linked