10 Jun 2021, 16:48
(This post was last modified: 10 Jun 2021, 16:51 by Travis Karschnik.)
Can I add human cell lines to the Taxonomic Applicability field of an AOP?
Human cell lines should not be listed in the taxonomic applicability field of an AOP. Applicability domain should refer to a taxonomic group, life stage, and sex of regulatory/management/decision-making significance. Since there is no regulatory aim to protect human cell lines, or to manage their exposure to chemicals or other stressors in the “real world” they are not relevant for defining the applicability domain of an AOP.
Human cell lines should not be listed in the taxonomic applicability field of an AOP. Applicability domain should refer to a taxonomic group, life stage, and sex of regulatory/management/decision-making significance. Since there is no regulatory aim to protect human cell lines, or to manage their exposure to chemicals or other stressors in the “real world” they are not relevant for defining the applicability domain of an AOP.