19 Jun 2023, 13:31
Sounds promising. In addition for concepts defined at a higher level we would need to think how to represents KERs from one upper level to another upper level KE that would allow for tissue specificity, complexity, interactions etc. E.g. ACE2 dysregulation (part of it: upregulation of enzymatic activity leads to X1 while Downregulation of protein on cell membrane leads to X2), where X may be a different upper level KE (e.g. microvascular dysfunction) consisting of different subevents X1, X2, ...Xi).