15 Feb 2022, 22:51
Highlights from Day 1 BOG 3
Community of Practice and Roles it Could Play
• Aggregation of training materials on one site, to make them more accessible to folks that are new to AOPs and want to learn.
• SAAOP as a coordination point for AOP/AOPN development focused around specific topical areas
• Current symposium was a good way those new to the area to get a feel for the diversity of AOP related efforts taking place
Incentives/Motivation for AOP Development
• The satisfaction of putting together various pieces of information to assemble knowledge
• A way to help tell a story from a body of data
• Serve as a handy reference even for the developers themselves to go back and refresh on a topic
• An effective way to bring lots of information together - similar to a review, but less likely to get buried amongst all the other literature and easier to update
Obstacles/hesitation related to AOP development
• The number of fields to fill out for an AOP description seems daunting
• There feels like a lot of redundancy between various fields and pages - is there a way to make that more efficient but still maintain modularity
Other discussion
• The role of evaluation of study quality in the process of developing AOPs - no simple way to impose a set of guidelines without a lot more burden on the authors
• The uncertainties and inconsistencies section of the KER pages as an important place to identify whether study quality issues may be a factor
• In general, filling in the uncertainties and inconsistencies section can be one of the most important parts of AOP development. Identifies where additional research may be needed.
Use of AOPs
• Searching for AOPs on a topic as a first source, before moving on to a literature search. If someone has already synthesized, can point you to the relevant information very quickly and efficiently
The "new thing" that AOPs really provide, compared to other types of biological networks or pathways is the assembly of weight of evidence. This is why filling in the evidence supporting the KERS is such a critical part of developing a high quality AOP.
Community of Practice and Roles it Could Play
• Aggregation of training materials on one site, to make them more accessible to folks that are new to AOPs and want to learn.
• SAAOP as a coordination point for AOP/AOPN development focused around specific topical areas
• Current symposium was a good way those new to the area to get a feel for the diversity of AOP related efforts taking place
Incentives/Motivation for AOP Development
• The satisfaction of putting together various pieces of information to assemble knowledge
• A way to help tell a story from a body of data
• Serve as a handy reference even for the developers themselves to go back and refresh on a topic
• An effective way to bring lots of information together - similar to a review, but less likely to get buried amongst all the other literature and easier to update
Obstacles/hesitation related to AOP development
• The number of fields to fill out for an AOP description seems daunting
• There feels like a lot of redundancy between various fields and pages - is there a way to make that more efficient but still maintain modularity
Other discussion
• The role of evaluation of study quality in the process of developing AOPs - no simple way to impose a set of guidelines without a lot more burden on the authors
• The uncertainties and inconsistencies section of the KER pages as an important place to identify whether study quality issues may be a factor
• In general, filling in the uncertainties and inconsistencies section can be one of the most important parts of AOP development. Identifies where additional research may be needed.
Use of AOPs
• Searching for AOPs on a topic as a first source, before moving on to a literature search. If someone has already synthesized, can point you to the relevant information very quickly and efficiently
The "new thing" that AOPs really provide, compared to other types of biological networks or pathways is the assembly of weight of evidence. This is why filling in the evidence supporting the KERS is such a critical part of developing a high quality AOP.