08 Oct 2024, 08:47
Hello,
My colleague and IĀ are trying to work with the ontologies that were used to annotated KEs, specifically under the KEC Biological Process. First going through all GO (gene ontology) terms, we are struggling to find all mappings of GO terms to genes (which is frequently done for gene set enrichment studies). Out of the 600-ish GO terms, we can not find about 10% of the terms using conventional mapping tools (GO package, MSigDb, ...). Manual searching indicates that GO terms might be obsolete and not anymore in the current versions of GO. Is there a way to find out which version of the ontology is used in AOP-Wiki, or whether there are updates to the ontologies used in the AOP-Wiki? For completeness, it would be great if such information can be found in the help page (https://www.aopwiki.org/info_pages/2/inf...ed_pages/7).
My colleague and IĀ are trying to work with the ontologies that were used to annotated KEs, specifically under the KEC Biological Process. First going through all GO (gene ontology) terms, we are struggling to find all mappings of GO terms to genes (which is frequently done for gene set enrichment studies). Out of the 600-ish GO terms, we can not find about 10% of the terms using conventional mapping tools (GO package, MSigDb, ...). Manual searching indicates that GO terms might be obsolete and not anymore in the current versions of GO. Is there a way to find out which version of the ontology is used in AOP-Wiki, or whether there are updates to the ontologies used in the AOP-Wiki? For completeness, it would be great if such information can be found in the help page (https://www.aopwiki.org/info_pages/2/inf...ed_pages/7).