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		<title><![CDATA[AOP Forum - General Questions about AOPs]]></title>
		<link>https://forum.aopwiki.org/</link>
		<description><![CDATA[AOP Forum - https://forum.aopwiki.org]]></description>
		<pubDate>Fri, 15 May 2026 02:59:19 +0000</pubDate>
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		<item>
			<title><![CDATA[AOP Design - herg inhibition leads to sudden death]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=177</link>
			<pubDate>Mon, 15 Nov 2021 18:05:49 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=566">Egemen</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=177</guid>
			<description><![CDATA[Dear All,<br />
<br />
I am a PhD student on toxicology and now trying to draft my content. The subject is herg inhibition eventually leads to sudden cardiac death. I have checked tons of literatures and for my draft design, please kindly check the attachment.<br />
<br />
But my problem here, I want to expand this pathway with the other KEs available in other AOPs. However, I am struggling to find to add other MIEs and/or KEs. They may not be available but i am not sure if it can be expanded.<br />
<br />
In addition, to create whole world with regards to my design, what platform do you recommend me to use?<br />
<br />
Hope, this will not make you confused :)<br />
<br />
Warm Regards,<br />
<br />
PS: I am not sure if you can see the attachment. Please let me know about it.]]></description>
			<content:encoded><![CDATA[Dear All,<br />
<br />
I am a PhD student on toxicology and now trying to draft my content. The subject is herg inhibition eventually leads to sudden cardiac death. I have checked tons of literatures and for my draft design, please kindly check the attachment.<br />
<br />
But my problem here, I want to expand this pathway with the other KEs available in other AOPs. However, I am struggling to find to add other MIEs and/or KEs. They may not be available but i am not sure if it can be expanded.<br />
<br />
In addition, to create whole world with regards to my design, what platform do you recommend me to use?<br />
<br />
Hope, this will not make you confused :)<br />
<br />
Warm Regards,<br />
<br />
PS: I am not sure if you can see the attachment. Please let me know about it.]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[AOP Evidence Data Model Pilot Study: Seeking Feedback!]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=171</link>
			<pubDate>Sun, 20 Jun 2021 20:41:17 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=23">JasonOBrien</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=171</guid>
			<description><![CDATA[Dear AOP Developers and AOP Users,<br />
<br />
The committee that oversees the development of the AOP-Wiki and AOP Knowledge Base (the OECD AOP-KB Subgroup) is currently considering modifications to the underlying database model that are aimed to improve the ease and transparency of how AOP information are collected, organized, reported and retrieved.<br />
<br />
Some of these data model proposals have been/will be presented at various venues (June OECD EAGMST Meeting, SETAC North America, etc…)<br />
THIS THREAD WILL BE UPDATED WITH LINKS TO THESE PRESENTATIONS ONCE THEY BECOME AVAILABLE<br />
<br />
<a href="https://drive.google.com/file/d/1pVzfdFW0e3W41_L5m4CkCoW8XB8UvkHT/view?usp=sharing" target="_blank" rel="noopener" class="mycode_url">Link 1: OECD EAGMST June 2021 Presentation</a><br />
<br />
<br />
In this forum thread we are seeking community feedback on your thoughts and impressions on these proposed data model modifications. Some specific questions for target end-users groups that we are seeking feedback on are:<br />
<br />
<span style="font-weight: bold;" class="mycode_b"><span style="text-decoration: underline;" class="mycode_u">AOP Developers:</span></span><br />
1) Do you think this model will make it easier or more difficult to input AOP evidence?<br />
2) If this model were implemented, would you be more or less likely to contribute?<br />
<br />
<span style="text-decoration: underline;" class="mycode_u"><span style="font-weight: bold;" class="mycode_b">AOP Users (regulatory, scientific, …):</span></span><br />
1) Does this model capture the information of greatest interest to you?<br />
2) What questions or issues do you normally try to address when you decide to access the AOP-Wiki?<br />
3) If you could design a search engine for the AOPwiki, what kind of searches would you like it to be able to conduct? What kind of inputs would you like the search to recognize? What kind of response (outputs) would you hope to get back?<br />
<br />
Of course we welcome any and all feedback! But if you are addressing any of these specific questions, please indicated which one in your response.<br />
Thank you for your help guiding the evolution of the AOP-KB! <br />
<br />
-The OECD AOP-KB Subgroup]]></description>
			<content:encoded><![CDATA[Dear AOP Developers and AOP Users,<br />
<br />
The committee that oversees the development of the AOP-Wiki and AOP Knowledge Base (the OECD AOP-KB Subgroup) is currently considering modifications to the underlying database model that are aimed to improve the ease and transparency of how AOP information are collected, organized, reported and retrieved.<br />
<br />
Some of these data model proposals have been/will be presented at various venues (June OECD EAGMST Meeting, SETAC North America, etc…)<br />
THIS THREAD WILL BE UPDATED WITH LINKS TO THESE PRESENTATIONS ONCE THEY BECOME AVAILABLE<br />
<br />
<a href="https://drive.google.com/file/d/1pVzfdFW0e3W41_L5m4CkCoW8XB8UvkHT/view?usp=sharing" target="_blank" rel="noopener" class="mycode_url">Link 1: OECD EAGMST June 2021 Presentation</a><br />
<br />
<br />
In this forum thread we are seeking community feedback on your thoughts and impressions on these proposed data model modifications. Some specific questions for target end-users groups that we are seeking feedback on are:<br />
<br />
<span style="font-weight: bold;" class="mycode_b"><span style="text-decoration: underline;" class="mycode_u">AOP Developers:</span></span><br />
1) Do you think this model will make it easier or more difficult to input AOP evidence?<br />
2) If this model were implemented, would you be more or less likely to contribute?<br />
<br />
<span style="text-decoration: underline;" class="mycode_u"><span style="font-weight: bold;" class="mycode_b">AOP Users (regulatory, scientific, …):</span></span><br />
1) Does this model capture the information of greatest interest to you?<br />
2) What questions or issues do you normally try to address when you decide to access the AOP-Wiki?<br />
3) If you could design a search engine for the AOPwiki, what kind of searches would you like it to be able to conduct? What kind of inputs would you like the search to recognize? What kind of response (outputs) would you hope to get back?<br />
<br />
Of course we welcome any and all feedback! But if you are addressing any of these specific questions, please indicated which one in your response.<br />
Thank you for your help guiding the evolution of the AOP-KB! <br />
<br />
-The OECD AOP-KB Subgroup]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[Modulating factors. Join the discussion]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=165</link>
			<pubDate>Tue, 11 May 2021 17:54:55 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=17">Brigitte Landesmann</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=165</guid>
			<description><![CDATA[Have you ever considered modulating factors (MFs) when developing your AOP?<br />
In the CIAO project we are developing an AOP network for COVID-19 <a href="https://www.ciao-covid.net/" target="_blank" rel="noopener" class="mycode_url">https://www.ciao-covid.net/</a> with MFs playing a big role.<br />
But we are facing the challenge on how to properly describe MFs in the Wiki. <br />
Has someone already gained experience with this? Please share your experience.<br />
In general, should we include MFs in AOP descriptions and if yes, how? What is everyone’s opinion on this?]]></description>
			<content:encoded><![CDATA[Have you ever considered modulating factors (MFs) when developing your AOP?<br />
In the CIAO project we are developing an AOP network for COVID-19 <a href="https://www.ciao-covid.net/" target="_blank" rel="noopener" class="mycode_url">https://www.ciao-covid.net/</a> with MFs playing a big role.<br />
But we are facing the challenge on how to properly describe MFs in the Wiki. <br />
Has someone already gained experience with this? Please share your experience.<br />
In general, should we include MFs in AOP descriptions and if yes, how? What is everyone’s opinion on this?]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[KER - Estrogen receptor agonism leading to reproductive dysfunction]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=127</link>
			<pubDate>Tue, 16 Feb 2021 15:36:43 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=24">DanV-AOP</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=127</guid>
			<description><![CDATA[Hello AOP forum - my research team is starting to work on a (non-adjacent) KER linking estrogen receptor agonism to reproductive dysfunction.  If you have interest in collaborating /contributing to this KER development, feel free to reach out.]]></description>
			<content:encoded><![CDATA[Hello AOP forum - my research team is starting to work on a (non-adjacent) KER linking estrogen receptor agonism to reproductive dysfunction.  If you have interest in collaborating /contributing to this KER development, feel free to reach out.]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[Help with General Questions about AOPs]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=79</link>
			<pubDate>Fri, 22 Jan 2021 16:19:38 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=6">Moderator KC</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=79</guid>
			<description><![CDATA[This forum is the place to ask any and all question you might have about AOPs.  Answers will be provided by other AOP forum members or moderators.<br />
<br />
All you need to do is make a new post, add a title that reflects your question and hit submit.]]></description>
			<content:encoded><![CDATA[This forum is the place to ask any and all question you might have about AOPs.  Answers will be provided by other AOP forum members or moderators.<br />
<br />
All you need to do is make a new post, add a title that reflects your question and hit submit.]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[Testing the forum]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=21</link>
			<pubDate>Tue, 15 Dec 2020 21:37:27 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=24">DanV-AOP</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=21</guid>
			<description><![CDATA[Hello All - did you get notified that a new thread was added to this forum?]]></description>
			<content:encoded><![CDATA[Hello All - did you get notified that a new thread was added to this forum?]]></content:encoded>
		</item>
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