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		<title><![CDATA[AOP Forum - Current AOP-Wiki features]]></title>
		<link>https://forum.aopwiki.org/</link>
		<description><![CDATA[AOP Forum - https://forum.aopwiki.org]]></description>
		<pubDate>Fri, 15 May 2026 02:50:24 +0000</pubDate>
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			<title><![CDATA[IMMINENT - AOP-Wiki Content Licensing]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=193</link>
			<pubDate>Thu, 11 Aug 2022 15:21:37 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=193</guid>
			<description><![CDATA[Originally, there was a feature “Hidden but searchable” foreseen, meaning that part of the AOP-Wiki content should be hidden from public viewing for a period of time that would suit the authors (embargo before peer reviewed publication or similar). In the meantime, the OECD body governing the AOP framework and the AOP-Wiki has decided that the current way of licensing AOP knowledge be modified and that this new license model would replace the “hidden but searchable” feature.<br />
<br />
The implementation for the new licensing model is <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">foreseen for AOP-Wiki release 2.6</span></span>, scheduled for the end of 2022.<br />
<br />
A description of what is foreseen can be found in the attachment <span style="font-weight: bold;" class="mycode_b">AOP-Wiki Content Licensing.pdf</span><br /><!-- start: postbit_attachments_attachment -->
<br /><!-- start: attachment_icon -->
<img src="https://forum.aopwiki.org/images/attachtypes/pdf.png" title="Adobe Acrobat PDF" border="0" alt=".pdf" />
<!-- end: attachment_icon -->&nbsp;&nbsp;<a href="attachment.php?aid=188" target="_blank" title="">AOP-Wiki Content Licensing.pdf</a> (Size: 602.03 KB / Downloads: 2)
<!-- end: postbit_attachments_attachment -->]]></description>
			<content:encoded><![CDATA[Originally, there was a feature “Hidden but searchable” foreseen, meaning that part of the AOP-Wiki content should be hidden from public viewing for a period of time that would suit the authors (embargo before peer reviewed publication or similar). In the meantime, the OECD body governing the AOP framework and the AOP-Wiki has decided that the current way of licensing AOP knowledge be modified and that this new license model would replace the “hidden but searchable” feature.<br />
<br />
The implementation for the new licensing model is <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">foreseen for AOP-Wiki release 2.6</span></span>, scheduled for the end of 2022.<br />
<br />
A description of what is foreseen can be found in the attachment <span style="font-weight: bold;" class="mycode_b">AOP-Wiki Content Licensing.pdf</span><br /><!-- start: postbit_attachments_attachment -->
<br /><!-- start: attachment_icon -->
<img src="https://forum.aopwiki.org/images/attachtypes/pdf.png" title="Adobe Acrobat PDF" border="0" alt=".pdf" />
<!-- end: attachment_icon -->&nbsp;&nbsp;<a href="attachment.php?aid=188" target="_blank" title="">AOP-Wiki Content Licensing.pdf</a> (Size: 602.03 KB / Downloads: 2)
<!-- end: postbit_attachments_attachment -->]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[IMPLEMENTED - De-emphasizing the role of stressors]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=185</link>
			<pubDate>Sun, 20 Feb 2022 08:53:27 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=185</guid>
			<description><![CDATA[AOPs are triggered by the interaction of a “stressor” (e.g. chemical, nanomaterial, radiation, virus, …) with the organism on molecular level, leading to the Molecular Initiating Event (MIE). The scope of the AOP Framework starts with the MIE and <span style="font-weight: bold;" class="mycode_b">does not explicitly include the stressor</span>, in other words, AOPs are “stressor-agnostic”. However, currently the AOP-Wiki includes a data object “Stressor”. This needs to be addressed by de-emphasising the role of stressors in the AOP-Wiki.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wik</span>i, <span style="font-weight: bold;" class="mycode_b">published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[AOPs are triggered by the interaction of a “stressor” (e.g. chemical, nanomaterial, radiation, virus, …) with the organism on molecular level, leading to the Molecular Initiating Event (MIE). The scope of the AOP Framework starts with the MIE and <span style="font-weight: bold;" class="mycode_b">does not explicitly include the stressor</span>, in other words, AOPs are “stressor-agnostic”. However, currently the AOP-Wiki includes a data object “Stressor”. This needs to be addressed by de-emphasising the role of stressors in the AOP-Wiki.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wik</span>i, <span style="font-weight: bold;" class="mycode_b">published on 17 July 2022.</span>]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[IMPLEMENTED - Modulating Factors]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=183</link>
			<pubDate>Sat, 19 Feb 2022 16:11:17 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=183</guid>
			<description><![CDATA[Modulating factors are extrinsic or intrinsic variables that, while not a direct causal element of an AOP, influence the response to the perturbation(s) represented in the AOP. They can be factors that convey greater or lesser sensitivity, can result in more, or less, severe effects, can alter time to effect(s) etc. Modulating factors act on one or more key event relationships (KERs) along the pathway. While they do not alter the causal connection between a pair of events, they do affect the quantitative attributes of the response-response relationship between those KEs.  However, because neither response-response relationships, nor the effect of modulating factors are always precisely defined in quantitative terms, the description of a modulating factor in the KER descriptions can range from qualitative to quantitative. Regardless, modulating factors should be supported by specific scientific evidence that establishes their overall effect on a given KER, which can include non-adjacent KERs (for example, linking the molecular initiating event directly to the adverse outcome). <br />
<br />
Modulating factors are viewed as important information to capture with regard to an AOP, as they can be critical for application and interpretation. However, to date very little information about relevant modulating factors has been captured in the KER descriptions. This is thought to be, in part, because the text field for modulating factors is embedded as a sub-field under the heading of “Quantitative Understanding”.  Given that “Quantitative Understanding” is a section that is often left blank in KER descriptions, moving “Known Modulating Factors” to a separate section, independent of the “Quantitative Understanding” may increase visibility and lead to more information about modulating factors being captured in the AOP-Wiki.<br />
<br />
A feature is therefore desirable in the AOP-Wiki to improve the capture of relevant modulating factor information during AOP development and, in the long term, increase the utility of that information for AOP users.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[Modulating factors are extrinsic or intrinsic variables that, while not a direct causal element of an AOP, influence the response to the perturbation(s) represented in the AOP. They can be factors that convey greater or lesser sensitivity, can result in more, or less, severe effects, can alter time to effect(s) etc. Modulating factors act on one or more key event relationships (KERs) along the pathway. While they do not alter the causal connection between a pair of events, they do affect the quantitative attributes of the response-response relationship between those KEs.  However, because neither response-response relationships, nor the effect of modulating factors are always precisely defined in quantitative terms, the description of a modulating factor in the KER descriptions can range from qualitative to quantitative. Regardless, modulating factors should be supported by specific scientific evidence that establishes their overall effect on a given KER, which can include non-adjacent KERs (for example, linking the molecular initiating event directly to the adverse outcome). <br />
<br />
Modulating factors are viewed as important information to capture with regard to an AOP, as they can be critical for application and interpretation. However, to date very little information about relevant modulating factors has been captured in the KER descriptions. This is thought to be, in part, because the text field for modulating factors is embedded as a sub-field under the heading of “Quantitative Understanding”.  Given that “Quantitative Understanding” is a section that is often left blank in KER descriptions, moving “Known Modulating Factors” to a separate section, independent of the “Quantitative Understanding” may increase visibility and lead to more information about modulating factors being captured in the AOP-Wiki.<br />
<br />
A feature is therefore desirable in the AOP-Wiki to improve the capture of relevant modulating factor information during AOP development and, in the long term, increase the utility of that information for AOP users.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[IMPLEMENTED - Strategy Fields]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=182</link>
			<pubDate>Sat, 19 Feb 2022 15:51:17 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=182</guid>
			<description><![CDATA[An important aspect of evaluating the quality and fit-for-purpose of an AOP is understanding how that AOP was developed and the overall approach to evidence assembly and evaluation that was employed. Additionally, other potential contributors to an AOP page can better understand what gaps might be filled through additional literature search or experimentation if there is some description of what strategies and approaches previous contributors have taken to assembling and evaluating supporting evidence. However, at present there are no text fields for describing the overall AOP development strategy on the AOP pages, nor the evidence collection and evaluation strategy on Relationship pages. A feature is desirable that provides free text fields for providing an overview of the strategies taken by the contributors.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in version <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[An important aspect of evaluating the quality and fit-for-purpose of an AOP is understanding how that AOP was developed and the overall approach to evidence assembly and evaluation that was employed. Additionally, other potential contributors to an AOP page can better understand what gaps might be filled through additional literature search or experimentation if there is some description of what strategies and approaches previous contributors have taken to assembling and evaluating supporting evidence. However, at present there are no text fields for describing the overall AOP development strategy on the AOP pages, nor the evidence collection and evaluation strategy on Relationship pages. A feature is desirable that provides free text fields for providing an overview of the strategies taken by the contributors.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in version <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[IMPLEMENTED - AOP Handbook (e-Handbook)]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=181</link>
			<pubDate>Sat, 19 Feb 2022 15:39:09 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=181</guid>
			<description><![CDATA[The AOP Handbook is currently a <a href="https://one.oecd.org/document/ENV/JM/MONO(2016)12/en/pdf" target="_blank" rel="noopener" class="mycode_url">static document</a> on the OECD website.<br />
This static document should be converted into an electronic handbook (e-Handbook) and published on the AOP-Wiki. It should always be clear under which handbook version a specific AOP was created/endorsed.<br />
<hr class="mycode_hr" />
This feature was <span style="color: #17b529;" class="mycode_color"><span style="font-weight: bold;" class="mycode_b">implemented </span></span><span style="color: #000000;" class="mycode_color">in<span style="font-weight: bold;" class="mycode_b"> </span></span>version <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[The AOP Handbook is currently a <a href="https://one.oecd.org/document/ENV/JM/MONO(2016)12/en/pdf" target="_blank" rel="noopener" class="mycode_url">static document</a> on the OECD website.<br />
This static document should be converted into an electronic handbook (e-Handbook) and published on the AOP-Wiki. It should always be clear under which handbook version a specific AOP was created/endorsed.<br />
<hr class="mycode_hr" />
This feature was <span style="color: #17b529;" class="mycode_color"><span style="font-weight: bold;" class="mycode_b">implemented </span></span><span style="color: #000000;" class="mycode_color">in<span style="font-weight: bold;" class="mycode_b"> </span></span>version <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></content:encoded>
		</item>
		<item>
			<title><![CDATA[IMPLEMENTED - Incorporation of third party tools]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=180</link>
			<pubDate>Sat, 19 Feb 2022 09:15:29 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=180</guid>
			<description><![CDATA[<span style="font-weight: bold;" class="mycode_b">Third party organizations</span> have been developing tools that can add functionality to the AOP-Wiki. However, the AOP-Wiki is not currently designed for the integration of third party tools. In order to facilitate their use, the AOP-Wiki should allow users <span style="font-weight: bold;" class="mycode_b">to seamlessly launch third party tools</span>.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in <span style="font-weight: bold;" class="mycode_b">r</span><span style="font-weight: bold;" class="mycode_b">elease 2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[<span style="font-weight: bold;" class="mycode_b">Third party organizations</span> have been developing tools that can add functionality to the AOP-Wiki. However, the AOP-Wiki is not currently designed for the integration of third party tools. In order to facilitate their use, the AOP-Wiki should allow users <span style="font-weight: bold;" class="mycode_b">to seamlessly launch third party tools</span>.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in <span style="font-weight: bold;" class="mycode_b">r</span><span style="font-weight: bold;" class="mycode_b">elease 2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></content:encoded>
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		<item>
			<title><![CDATA[IMPLEMENTED - Filter and sort tables]]></title>
			<link>https://forum.aopwiki.org/showthread.php?tid=179</link>
			<pubDate>Sat, 19 Feb 2022 09:11:26 +0000</pubDate>
			<dc:creator><![CDATA[<a href="https://forum.aopwiki.org/member.php?action=profile&uid=12">Clemens Wittwehr</a>]]></dc:creator>
			<guid isPermaLink="false">https://forum.aopwiki.org/showthread.php?tid=179</guid>
			<description><![CDATA[A feature is desirable for the display of tabular information where the user is able to <span style="font-weight: bold;" class="mycode_b">filter the display of tabular information</span> similar to the function in Excel. This feature is especially important for the main AOP table.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></description>
			<content:encoded><![CDATA[A feature is desirable for the display of tabular information where the user is able to <span style="font-weight: bold;" class="mycode_b">filter the display of tabular information</span> similar to the function in Excel. This feature is especially important for the main AOP table.<br />
<hr class="mycode_hr" />
This feature was <span style="font-weight: bold;" class="mycode_b"><span style="color: #17b529;" class="mycode_color">implemented </span></span>in release <span style="font-weight: bold;" class="mycode_b">2.5 of the AOP-Wiki, published on 17 July 2022.</span>]]></content:encoded>
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