<![CDATA[AOP Forum - AOP Guidance]]> https://forum.aopwiki.org/ Fri, 15 May 2026 02:50:29 +0000 MyBB <![CDATA[Request for Coach]]> https://forum.aopwiki.org/showthread.php?tid=173 Wed, 14 Jul 2021 00:05:01 +0000 Shihori Tanabe]]> https://forum.aopwiki.org/showthread.php?tid=173 Dear Content Developers - please post your AOP proposal, page ideas, or areas of interest here if you would like to be paired with a coach for assistance in content development.]]> Dear Content Developers - please post your AOP proposal, page ideas, or areas of interest here if you would like to be paired with a coach for assistance in content development.]]> <![CDATA[Stressor fields]]> https://forum.aopwiki.org/showthread.php?tid=128 Tue, 16 Feb 2021 15:37:49 +0000 DanV-AOP]]> https://forum.aopwiki.org/showthread.php?tid=128
A couple things to keep in mind about "stressors" identified in relation to an AOP:

  • AOPs are chemical agnostics
  • The "stressor" field is not intended to provide a comprehensive list of stressors that can activate an AOP.
  • The AOP pages are intended moreso to identify "prototypical stressors" as those upon which a lot of the weight of evidence for the AOP is based.  This will generally be just one or a handful.
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A couple things to keep in mind about "stressors" identified in relation to an AOP:

  • AOPs are chemical agnostics
  • The "stressor" field is not intended to provide a comprehensive list of stressors that can activate an AOP.
  • The AOP pages are intended moreso to identify "prototypical stressors" as those upon which a lot of the weight of evidence for the AOP is based.  This will generally be just one or a handful.
]]> <![CDATA[OECD Series on Adverse Outcome Pathways]]> https://forum.aopwiki.org/showthread.php?tid=19 Tue, 15 Dec 2020 15:35:24 +0000 Moderator KC]]> https://forum.aopwiki.org/showthread.php?tid=19 OECD Series on Adverse Outcome Pathways

This is a link to the AOPs that have been reviewed and published by OECD.

https://www.oecd-ilibrary.org/environmen...s_2415170x]]> OECD Series on Adverse Outcome Pathways

This is a link to the AOPs that have been reviewed and published by OECD.

https://www.oecd-ilibrary.org/environmen...s_2415170x]]> <![CDATA[OECD AOP Guidedance and Handbook Documents]]> https://forum.aopwiki.org/showthread.php?tid=7 Mon, 14 Sep 2020 18:40:52 +0000 Moderator KC]]> https://forum.aopwiki.org/showthread.php?tid=7 Here is a link to the OECD AOP Handbook

This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying, organising and evaluating critical information on key events (KEs) as well as linkages between KEs within the AOP (i.e. AOP development). It also provides explicit guidance on how to assess the weight of evidence (WoE) supporting the overall AOP and its relevance for life stage, sex and taxonomy (i.e. AOP evaluation). This handbook is not intended to provide a review or summary of the literature informing the AOP concept. Instead, it focuses on practical aspects of AOP development and assessment. It has been developed by a subgroup of the OECD Extended Advisory Group for Molecular Screening and Toxicogenomics (EAGMST).

https://www.oecd-ilibrary.org/environmen...m9d1g32-en]]> Here is a link to the OECD AOP Handbook

This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying, organising and evaluating critical information on key events (KEs) as well as linkages between KEs within the AOP (i.e. AOP development). It also provides explicit guidance on how to assess the weight of evidence (WoE) supporting the overall AOP and its relevance for life stage, sex and taxonomy (i.e. AOP evaluation). This handbook is not intended to provide a review or summary of the literature informing the AOP concept. Instead, it focuses on practical aspects of AOP development and assessment. It has been developed by a subgroup of the OECD Extended Advisory Group for Molecular Screening and Toxicogenomics (EAGMST).

https://www.oecd-ilibrary.org/environmen...m9d1g32-en]]>