I'm not sure what kinds of stressors I should identify on my AOP page.

• AOPs are chemical agnostics
  
• The "stressor" field is not intended to provide a comprehensive list of stressors that can activate an AOP.
  
• The AOP pages are intended moreso to identify "prototypical stressors" as those upon which a lot of the weight of evidence for the AOP is based.  This will generally be just one or a handful.
  

Hello AOP forum - my research team is starting to work on a (non-adjacent) KER linking estrogen receptor agonism to reproductive dysfunction.  If you have interest in collaborating /contributing to this KER development, feel free to reach out.

We are building a community of trainers for exchange and sharing of experience and material and to improve the currently available offer in AOP training. Would you like to become an AOP champion and promote the development and application of AOPs within your community?
Also your feedback and input to existing training programmes would be very valuable.
We´d be happy to welcome you in the community.

 

This forum is the place to ask any and all question you might have about AOPs.  Answers will be provided by other AOP forum members or moderators.

All you need to do is make a new post, add a title that reflects your question and hit submit.

Hello All - did you get notified that a new thread was added to this forum?

OECD Series on Adverse Outcome Pathways

This is a link to the AOPs that have been reviewed and published by OECD.

https://www.oecd-ilibrary.org/environmen...s_2415170x

Public resources available for anyone who wishes to learn more about, or begin to devlop their own AOPs
Online tools
OECD Webinar Series introducing AOPs, uses and case studies
https://www.oecd.org/chemicalsafety/test...logies.htm
The OECD User’s Handbook supplement to the guidance document for developing and assessing AOPs, Series on Testing and Assessment no. 233; Series on Adverse Outcome Pathways No. 1 (OECD 2018): complete instructions for every step and every field of the AOP Wiki
https://one.oecd.org/document/ENV/JM/MON...)12/en/pdf
OECD´s webiste on the OECD program: decribes the background
http://www.oecd.org/chemicalsafety/testi...nomics.htm
OECD´s website on Integrated Approaches to Testing and Assessment (IATA) describes what IATA are and their applications, and links to relevant documents
http://www.oecd.org/chemicalsafety/risk-...ssment.htm
OECD guidance document for the use of AOPs in developing IATA, series on testing and assessment No 260 (OECD 2016)
http://www.oecd.org/officialdocuments/pu...anguage=en

The AOP Wiki https://aopwiki.org/
There are important policies to read before you start working in the Wiki - there is a help page, and writing and editing policy, as well as the link to help you create an account:
https://aopwiki.org/#Before%20you%20start
https://aopwiki.org/wiki/index.php/AOP_W...nts_Policy
https://aopwiki.org/users/sign_up

AOP ONLINE COURSE
3 modules
- history and overview
- AOP Wiki tutorial and quizzes
- Self Exam
https://aopwiki.org/training/wiki/

Coursera lecture available through Johns Hopkins School of Public Health (free)
https://www.coursera.org/lecture/toxicol...tive-xwWPg

Other lectures and videos available online

SETAC 2015 CE Course: Developing and Applying Adverse Outcome Pathways. WHat you need to know
Part 1: http://setac.sclivelearningcenter.com/in...SID=215605
Part 2: http://setac.sclivelearningcenter.com/in...SID=215606

SOT CE Course "AOP Deveoplment and Application"

Society for the Advancement of AOPs Training videos:
http://www.saaop.org/workshops/AOPs_Wiki_July2017.html
http://www.toxicology.org/education/ce/o...ourses.asp - subscription required

Other training resources - Effoctopedia:
https://training.effectopedia.org
https://training.effectopedia.org/course...#section-1

A full list of available AOP training at the Animal Free Safety Assessment (AFSA) website:
https://www.afsacollaboration.org/tox21/get-trained/

ChemicalWatch published two articles about AOPs in 2019.
• In July 2019, ChemicalWatch published an article about the AOP Framework Study facilitated by the JRC.
o https://chemicalwatch.com/79660/jrc-laun...way-survey
• In April 2019, ChemicalWatch published an article on how scientists from US EPA and Environment and Climate Change Canada have networked existing adverse outcome pathways (AOPs) to reveal thousands of potential new toxicity mechanisms.
o https://chemicalwatch.com/76274/aop-know...mechanisms

Upcoming Meetings/Symposia/Workshops/Training on AOPs

1> The QSAR 2020 meeting will be held in Durham North Carolina from June 8 -11.  And it includes a training session entitled “AOP Hands-on Training: Building the Foundation for Predictive Toxicology”.  https://www.ascctox.org/qsar2020/qsar-2020-program[/font]

2>  The Human Toxicology Project Consortium and Physicians Committee for Responsible Medicine will once again co-sponsor an ancillary session on AOPs at the Society of Toxicology’s (SOT) annual meeting in Anaheim, CA: What AOPs can do for you: an introduction and hands-on experience, Hilton Anaheim, 4:45pm - 6:45pm, Mar 16, 2020.

Here is a link to the OECD AOP Handbook

This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs). It provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying, organising and evaluating critical information on key events (KEs) as well as linkages between KEs within the AOP (i.e. AOP development). It also provides explicit guidance on how to assess the weight of evidence (WoE) supporting the overall AOP and its relevance for life stage, sex and taxonomy (i.e. AOP evaluation). This handbook is not intended to provide a review or summary of the literature informing the AOP concept. Instead, it focuses on practical aspects of AOP development and assessment. It has been developed by a subgroup of the OECD Extended Advisory Group for Molecular Screening and Toxicogenomics (EAGMST).

https://www.oecd-ilibrary.org/environmen...m9d1g32-en